解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Seasonal variation in the antioxidant activity and content of phenolic compounds was studied for the 70% methanol extracts of Sorbus aucuparia leaves harvested monthly over the full course of the growing season. The antioxidant potential of the extracts was evaluated using two complementary in vitro tests: the DPPH (2...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2011-11-01 00:00:00
abstract::A series of 1,2,4-trisubstituted-1H- imidazole derivatives (4a-o) was synthesized by reacting 2,4-disubstituted-1H-imidazoles (3a-o) with chlorobenzene in the presence of triethylamine. Phenylglyoxal (2) was reacted with different aromatic aldehydes in the presence of ammonium acetate and glacial acetic acid to afford...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2011-09-01 00:00:00
abstract::In the recent years a significant development of investigations with regard to bioavailability of ocular drugs has been noticed. The corneal epithelial barrier is the main pathway for ocular penetration of topically applied ophthalmic drugs into the anterior chamber. To work out an in vitro model of bovine corneal epi...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2011-09-01 00:00:00
abstract::The aim of the work was to compare two analytical methods of trace analysis in respect to their applicability in heavy metals determination in biological samples. Atomic absorption spectrometry (AAS) may be considered as the method of choice in such analyses due to its accuracy, precision and low detection limit. On t...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2011-07-01 00:00:00
abstract::The objective of the present work was to optimize the formulation of fast disintegrating tablets (FDTs) of ondansetron HCl containing novel superdisintegrants, possessing sufficient mechanical strength and disintegration time comparable to those containing crospovidone or croscarmellose sodium. The FDTs were formulate...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2011-07-01 00:00:00
abstract::A new series of (benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl) pyrimidine derivatives were synthesized from 3-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-carbaldehyde (1) through different routes of cyclocondensation reactions. Condensation of 1 with active methylene compounds afforded compounds 2-8. The cyclization of 2 wit...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2011-05-01 00:00:00
abstract::It were established and validated the conditions of voltammetric determination of copper in pharmaceutical preparations. The three selected preparations: Zincuprim (A), Wapń, cynk, miedź z wit. C (B), Vigor complete (V) contained different salts and different quantity of copper (II) and increasing number of accompanie...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2011-03-01 00:00:00
abstract::The release of diclofenac sodium and papaverine hydrochloride from tablets and pellets using the flow-through cell apparatus was studied. The influence of excipients and of a size of the solid dosage forms on the amount of the released substances at the intervals of time using the different rates of flow of the dissol...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2011-03-01 00:00:00
abstract::6-Aminocoumarin on treatment with oxalyl chloride gives coumarinyl-6-isocynate (1a-c) which on treatment with glycine gives 1H-3-[2'-oxo-2'H-benzopyran-6'-yl]-5-imidazolidine-2, 4-dione (2a-c). (2a-c) when refluxed with o-chlorobenzaldehyde, m-hydroxybenzaldehyde, 3,4-dimethoxybenzaldehyde and 3-nitrobenzaldehyde sepa...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Alginate based mineral oil entrapped emulsion gel (MOEG) buoyant beads of domperidone were prepared by emulsion gelation technique. The prepared beads were evaluated for particle size, surface morphology, buoyancy, actual drug content and entrapment efficiency. Effect of different oils (castor oil, olive oil and linse...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Casein kinase II (CK2) is the most pleiotropic of all protein kinases with more than 300 substrates implicated in a wide variety of cellular functions as signal transduction, proliferation and cell survival. Increased levels of CK2 has been demonstrated in a number of cancers, where it regulates the activity of variou...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2010-11-01 00:00:00
abstract::This is a review of analytical methods, such as spectrophotometry, derivative spectrophotometry and various chromatographic (gas chromatography-GC, high-performance liquid chromatography-HPLC, thin-layer chromatography-TLC, high-performance thin-layer chromatography-HPTLC, liquid chromatography-tandem mass spectrometr...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章,评审
doi:
更新日期:2010-09-01 00:00:00
abstract::The present study was undertaken to develop oral sustained release tablets of metoprolol tartrate using natural hydrophilic matrix formers (xanthan gum and tragacanth). Sustained release matrix tablets of metoprolol tartrate were prepared by using different ratios of drug, xanthan gum and tragacanth. Microcrystalline ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
abstract::Abstract: Reaction of 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetyl chloride 2 with various N'-(substituted aryl)-p-aminobenzenesulfonamide derivatives afforded title compounds. All the final compounds were characterized by the IR spectral data and elemental analysis and screened for antibacterial activity against ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2010-07-01 00:00:00
abstract::The present investigation was an attempt to evaluate the anti-inflammatory effect of a polyherbal preparation (Sudarshanam Oil) on hematological parameters in Wistar rats. This polyherbal formula contains main ingredients of Tinaspora Cordifolia, Curcuma longa, Terminalia chebula, Emblica officinalis, Andrographis pan...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2010-05-01 00:00:00
abstract::Conditions have been elaborated for the identification of all the compounds belonging to the group of angiotensin convertase inhibitors: lisinopril, quinapril, ramipril, spirapril, moexipril, trandolapril, benazepril, cilazapril, fosinopril, captopril, enalapril, imidapril and zofenopril by thin-layer chromatography. ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2010-03-01 00:00:00
abstract::Some new biphenyl-4-carboxylic acid 5-(arylidene)-2-(aryl)-4-oxothiazolidin-3-yl amides have been synthesized and evaluated for anti-inflammatory activity. Biphenyl-4-carboxylic acid hydrazide was converted to the corresponding aryl hydrazones using aryl aldehydes in the presence of catalytic amount of glacial acetic ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::In the present study the series of spirosuccinimides with the aromatic ring at the imide nitrogen atom was synthesized. All the compounds were tested for their anticonvulsant activity in the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) screens. The neurotoxic properties were determined applyi...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2009-11-01 00:00:00
abstract::The functional gastrointestinal diseases (FGIDs) are often noticed disturbances. Functional dyspepsia (FD) is the most frequent FGID of the upper part of the gastrointestinal tract while irritable bowel syndrome (IBS) occurs in the lower gastrointestinal part. Both clinical entities are characterized by rich symptomat...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章,评审
doi:
更新日期:2009-09-01 00:00:00
abstract::Aqueous extract of the roots of Radix paeoniae (Paeonaceae) was screened for wound healing by excision, incision and dead space wound models on Wistar rats. The parameters studied were breaking strength in case of incision wounds, epithelialisation and wound contraction in case of excision wound and granulation tissue...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2009-09-01 00:00:00
abstract::A series of N-{(substituted)1,3-benzothiazol-2-yl}-1,1 '-biphenyl-4-carboxamides was synthesized by reaction between biphenyl acid chloride and 2-aminobenzothiazole. The synthesized compounds were screened in vivo for diuretic activity. Among the series, N-(1,3-benzothiazol-2-yl)-1,1'-biphenyl-4-carboxamide (II) was f...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
abstract::The aim of this paper was to validate an analytical method for the simultaneous determination of PTX and its active metabolite (-)-(R)-M1 in rat serum and some tissues using a high-performance liquid chromatography method with ultraviolet detection (HPLC-UV). The specificity, linearity, precision, accuracy, recovery, ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2009-05-01 00:00:00
abstract::A new isoflavone (1) isolated from the roots of Flemingia strobilifera (L) R. Br. was identified as 5,7,4'-trihydroxy 8,2',5'-tri(3-methylbut-2-enyl)isoflavone along with the known phytoconstituents: 5,7,2',4'-tetrahydroxyisoflavone (2), 5,7,4'-trihydroxyisoflavone (3) and beta-sitosterol (4). Structure assignments we...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2009-05-01 00:00:00
abstract::Several heteroaryl semicarbazones were prepared by the reaction of heteroaryl hydrazine carboxamide with aryl aldehydes or ketones. The structures of the synthesized compounds were confirmed by spectral data and elemental analyses. Compounds were tested for anticonvulsant activity utilizing pentylenetetrazole-induced ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00
abstract::Synthesis of 2-(2-hydroxy-3-amino)propyl derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones (24-35) is described. The chlorides used in the above synthesis exist mainly in the cyclic forms (18, 20-23). Only chloride with benzhydryl substituent at the nitrogen atom of piperazine has the chain str...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::We examined the effect of the opioid receptor agonists and the effect of an antioxidant selol, which is an organoselenium compound on antinociceptive action of opioid agonists in diabetic neuropathic pain model. Streptozotocin (STZ) induced hyperglycemia accompanied by a prolonged decrease in nociceptive threshold is ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2008-11-01 00:00:00
abstract::A series of 5-amino-3-methyl-4-isoxazolecarboxylic acid semicarbazides and thiosemicarbazides (M1-M9) were obtained by reacting 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide with isocyanate and isothiocyanate. In order to determine structure-activity relationships for the series of nine compounds (M1-M9) geome...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract::Determination of oxidation phenotype is used to obtain the best results of pharmacotherapy and to explain a lower efficiency of some drugs in particular patients. The purpose of the present study was to determine the distribution of CYP2D6 metabolizer status in subjects from central Poland, using dextromethorphan as t...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract::Differential scanning calorimetric (DSC) curves recorded for ornidazole drug during heating and cooling showed that the drug which melted around 86.1 degrees C undercooled to well below ambient room temperature of 27 degrees C during the cooling cycle. The undercooled melt kept in the freezer at 0 degree C for 10 days...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2008-07-01 00:00:00
abstract::Boa constrictor is one of the snakes found in the riverine areas of Nigeria, especially in the Niger Delta regions. The fat obtained from the snake is used ethno-medicinally for the treatment of burns and inflammatory conditions. The purpose of this study was to validate the traditional use of this crude fat and oil. ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2008-07-01 00:00:00
abstract::In the human organism 58 cytochrome P450 (CYP) isoenzymes belonging to 18 families have been described. These hemoproteins, with enzymatic activity characteristic for monooxygenases, show a broad affinity for chemically differentiated endo- or exogenous compounds, including drugs. CYP isoenzymes participate in metabol...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2008-05-01 00:00:00
abstract::The goal of this study was to analyze antibacterial drug prescribing in the 1-million-plus, strictly defined population in Poland. For the 2002-2005 years, data from National Health Fund on outpatient purchasing of antibiotics in Lubuskie's Province were collected and expressed in DDD per 1-thousand inhabitants per da...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2008-05-01 00:00:00
abstract::A series of 2,3-dihydro-7-nitroimidazo[5,1-b]oxazoles has been prepared in one-pot reaction. The proposed new method of their synthesis requires a treatment of 4,5-dinitroimidazole or 2-methyl-4,5-dinitroimidazole with oxiranes. Some of the obtained compounds have been tested in vitro for antimycobacterial activity an...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::Matrix formulations of Eudragit E 100: NE 40D polymers (100:0, 70:30, 60:40, 50:50% w/w) with 20% w/w of triacetine and 5% w/w of atenolol were prepared by film casting method with different solvents (methanol, 2-propanol and acetone). In vitro release of atenolol from the films were studied by vertical Franz diffusio...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::Combination therapy with protease inhibitors (PIs) is used for the treatment of patients infected with the human immunodeficiency virus (HIV). To achieve optimal drug concentrations for viral suppression and avoidance of drug toxicity, therapeutic drug monitoring of PIs levels has been considered essential. In this st...
journal_title:Acta poloniae pharmaceutica
pub_type: 临床试验,杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::We analyzed expression of genes participating in apoptotic and oncogenesis processes under influence of paclitaxel applied in treatment of breast carcinoma. Analysis showed, that in a group of cells where paclitaxel was administered at lower dose (60 ng/mL) it caused statistically significant increase of expression of...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::Spectral properties of 2, 6, 6-trimethyl-3-carbmethoxy-4-phenyl-5-oxo -1,4,5,6,7,8-hexahydroquinoline derivatives (HHQ) with different substituents in the phenyl ring (-Cl, -NO2, -CF3, -CH3, -OCH3) have been studied. Their emission and absorption spectra have been analyzed and quantum yields of emission were determine...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract::The plant of Phyllanthus amarus is used as diuretic and to lower blood pressure in traditional medicine practice. The effect of the aqueous extract of the leaves of Phyllanthus amarus on blood pressure was evaluated in normotensive male rabbits. Intravenously administered aqueous doses (5 mg to 80 mg/kg) of the extrac...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract::The present investigation was an attempt to evaluate the possible ameliorative effect of curcumin on aflatoxin-induced lipid peroxidation in liver, kidney and testis of mice in vitro. Tissues were collected from healthy Swiss strain male albino mice Mus musculus weighing 30-35 g. The homogenates were treated with afla...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
abstract::The complexes of Co(II), Ni(II) and Cu(II) with N,N'-bis-[5-X-salicylidene]-4,4'-diaminodibenzyl, abbreviated as H2-XSalPDADB (X = -H, -CH3, -Br) have been synthesized and investigated by elemental analysis, electrical conductance, magnetic, spectral and thermal studies. The molar conductivity data indicate that the c...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00